Sunifiram, a compound that excites AMPA receptors (conduits for synaptic transmissions throughout the central nervous system), is a newcomer to the nootropic market. It is placed into the ampakine family of compounds and is documented to be 1000x more potent than Piracetam in similar doses.



First researched in 2000, sunifiram was found to be a potent AMPA agonist, meaning that its primary purpose is to excite AMPA receptors within the central nervous system to promote an increased level of synaptic activity. This boosted activity level results in a higher production of the compound glutamate, which is one of the most important neurotransmitters in the brain. Glutamate directly influences the brain’s metabolism, as well as the efficiency of its synaptic processes. Because of this, a low level of glutamate can result in the impairment of focus and capacity to hold onto information. Sunifiram’s glutamate encouragement has been found to lead to enhanced memory functionality, decision making processes, learning potential, and alertness in its users.

Side effects & Dosages

Because of Sunifiram’s high level of concentration it is an incredibly potent substance. Doses as small as 4 mg are enough to bring about positive effects in its users, though most consumers generally take 5-8 mg at a time. Harmful, addictive side effects tend to come about once doses of 10 mg and above are taken. At that point, Sunifiram takes on a psychostimulant level of side effects similar to compounds like Adderall. At that level, side effects can include but are not limited to: coldness, numbness, discoloration in the skin (signs of blood flow issues), and mood and behavior changes. Dry mouth, a loss of appetite, and anxiety are common as well.

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