Resveratrol is a natural phenol stilbenoid found in grapes and other fruits. Resveratrol is known to be a potent anti-oxidant, providing excellent protection against oxidative damage throughout the entire body. It also increases circulation via vasodilation, lowers LDL cholesterol, and promotes the release of the adrenal hormone norepinephrine. This leads to the main cognitive benefits of increased mental focus, a greater sense of alertness, and increased attention span.

The compound has also been linked to longevity, activating genes which could dramatically prolong lifespan. Resveratrol is difficult to supplement because it is not very bioavailable and much of it is lost during the digestion process. For this reason, Pterostilbene may be more effective in a nootropic stack.



Resveratrol’s most well-known benefit is that it can extend the lifespan of certain cells by as much as 70%, and it also appears to act as a type of anti-oxidant. In laboratory studies, it is an effective free radical scavenger, along with a number of other oxidants. This supplement also helps to activate important cellular anti-oxidant defenses by producing a number of internal enzymatic anti-oxidants like glutathione, catalase, and others.

There a number of other competing theories about how Resveratrol might work, but these still need to be more thoroughly studied. It is thought to possibly inhibit platelet aggregation and also promote vasodilation, or the opening/widening of blood vessels. This is done through the production of Nitric Oxide.

In terms of its effects on cognitive enhancement, resveratrol is known to stimulate norepinephrine release at a moderate level. Norepinephrine is one of the adrenal hormones that promotes sensations of mental alertness and heightens our attention and perceptual awareness.

This could explain why users feel that their concentration and mental stamina is boosted when taking this supplement, nevermind the fact that it is also a MAO-Inhibitor as well as a serotonin agonist. As a result, it may help to improve a user’s mood, reduce their anxiety, and even lead to a better quality of rest.

Side Effects & Dosages

Resveratrol does appear to be a fairly safe supplement which is very well-tolerated in humans. In fact, doses as high as 5 grams (which are not recommended) have been taken with only a bit of mild stomach upset and nausea. No dangerous side effects have been reported so far when taking Resveratrol.

Medical professionals within the health community have not yet established a definitively recommended dose for Resveratrol. Studies and evidence indicate that for those who are unhealthy and looking to improve their overall cardiovascular health, insulin sensitivity, and longevity, starting with as little as 10 mg per day can be helpful.

For otherwise healthy adults, anywhere between 100 and 500 mg is acceptable. As with anything new, always begin with the lowest effective dose. Only increase your dosage once becoming familiar with its effects, and even then do so carefully in a slow and controlled manner.

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