Discovered in 1819 when it was isolated as an alkaloid of the Piper nigrum plant (commonly known as a pepper vine), Piperine is a component of the widely-used spice pepper. In supplement form, this alkaloid is combined with the geometric isomer chavicine. Piperine increases metabolism and facilitates the transport of key nutrients throughout the body. Piperine functions as a natural Monoamine oxidase inhibitor (MAOI), preserving levels of dopamine and serotonin.

Its benefits include anti-depressive qualities. Higher levels of dopamine and serotonin can dramatically increase its user’s mood and provide strong levels of energy. Concentration and attention span are heightened, and motivation to complete tasks is improved. Overall, Piperine increases the bioavailability of other natural nutrients. It also acts as an immunomodulator, providing backup for the body’s overall immune response.



One of the most interesting effects of Piperine is that of helping to increase the absorption of a number of other nutrients, such as vitamin C, selenium, beta-carotene, vitamin A, vitamin B-6, and CoQ10 (coenzyme Q 10). Not only does it increase their absorption, but it also serves to enhance the bio availability of these supplements.

As an example, studies have demonstrated that it helps to increase the absorption of CoQ10 by around 30 percent, but it also enhances the bioavailability of this supplement by as much as 20 times.

Another interesting aspect of Piperine is its apparent thermogenesis effects. Normally this would be something which was associated only with weight loss, but Piperine does seem to play a vital role in helping the body to utilize the food consumed each day.

In other words, it helps to spark or speed up the metabolism and metabolic processes, providing a more efficient mode of nutrient transportation to the blood. It is even thought to help in a number of seemingly unrelated processes like reducing pain, inflammation, and possibly even combating arthritis.

There are several published studies that have looked at the effects of Piperine on cognitive processing. One study in the Journal of Traditional Medicine found positive impacts from the use of this supplement on memory and behavior metrics.

This performance increase seems to be mediated by monoamine neurotransmitters, suggesting that Piperine acts in a similar way to Monoamine Oxidase Inhibitors. The result is higher levels of Dopamine and Serotonin activity, leading to diverse improvements in mental abilities and factors related to mood.

A 2008 study indicates that Piperine may also have some anti-cancer properties. The study showed that this supplement was able to inhibit the growth of colon cancer cells that were grown in a lab. Of course, more research would be needed to test and prove this hypothesis. There is also some evidence to suggest that Piperine may have a bit of anti-depressant activity as well.

Side Effects & Dosages

This supplement is generally considered to be safe, but there do seem to be a number of unanswered questions regarding the effects of Piperine. For example, it may possibly increase the effects of medications and drugs which are already in use. Do not take this at the same time as any prescription medications, certainly not until getting it cleared by a doctor or qualified medical professional.

It should be noted Piperine it is a very potent supplement. Many experts believe that at any dosage above about 15 mg per day, it might begin to affect the absorption and metabolism of a wide range of drugs and supplements. Therefore, be very diligent about using this in combination with other supplements, drugs, and medications. Begin very low, at a dose of about 5 to 10 mg per day.

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