Also known as Noofen, Fenibut, or Phenybut, Phenibut is a fully bioavailable derivative of GABA, a crucial neurotransmitter that balances stressful activity in the brain by working with key neural receptor sites before other hormones are able to. It is used primarily to reduce stress and enhance feelings of calm and focus within the central nervous system, and at abusive doses can pose dangerous health risks.



GABA is organically released throughout the central nervous system as an inhibitory neurotransmitter; as a result it has a poor bioavailability and cannot be supplemented reliably by artificial means. Phenibut is a modified version of GABA, and with its different properties can easily cross the blood-brain barrier (a filtration membrane that surrounds the brain) to work its effects. This is due to the addition of a phenyl group molecule to GABA’s organic composition.

After Phenibut reaches the brain, it stimulates two types of GABA receptors: GABA-A and GABA-B. These receptors, once stimulated, work to lower feelings of anxiety and stress within the central nervous system. They can also ease muscle tension and lower a user’s inhibitions, similarly to alcohol. They create these effects by easing the activity that neurons put themselves through when communicating to one another via electrical synapses within the brain. By controlling any potential over-activity by these neurons, Phenibut helps to relax the brain and assist in its focus. Users generally report that Phenibut supplementation creates feelings of serenity and wholesomeness.

Side Effects and Dosages

If abused, Phenibut can have dangerous side effects. For healthy adults it is safe to supplement in small amounts, but at higher quantities Phenibut can impair the body in much the same ways that alcohol and Benzodiazepines (sometimes called “Benzos”) can. In addition, taking Phenibut with other GABA agonists (GABAergics) is discouraged due to the potential serious risks that could come from their combinations.

Common side effects can include headaches and lightheadedness, stomach pains, and nausea. Memory loss and unconsciousness is possible as well.

It is generally recommended to supplement with Phenibut for only a few weeks at a time. Tolerance to this supplement can occur as soon as five days after initial consumption, and recommended dosages start at 250 mg daily. In the United States, Canada, the United Kingdom, and Australia, Phenibut is listed as an uncontrolled substance, meaning that it is legal to obtain and consume without a prescription or license, so care should be taken with its use.

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