A synthetic form of CoQ10 made with a shorter chained quinone compound, Idebenone’s chemical structure makes it more bioavailable than comparable amounts of CoQ10. It can also cross the blood-brain barrier which makes it superior to CoQ10 for nootropic purposes. Like CoQ10, Idebenone is a powerful anti-oxidant, which scavenges the body for free radicals. In this way, Idebenone protects the cells of the body from oxidative damage.

Idebenone increases NGF (Nerve Growth Factor), a protein which directly assists in the growth and repair of neurons and nerve cells in the brain. Idebenone also regulates the absorption of choline within the brain. Its user benefits include stronger metabolism, easy access to memory, and heightened states of concentration. Over the long term, Idebenone supplementation can have significant neuroprotective qualities.



While CoQ10 is very effective at producing energy in your mitochondria, the main downside is the fact that it needs a constant supply of oxygen to function properly.

If this is not present, or conditions create a dangerously low level of oxygen (like a stroke or heart attack, for example) the enzyme itself actually breaks down and leads to the release of free radicals that can damage cells and organs.

Idebenone, on the other hand, does not break down nearly as quickly. Being a shorter chained quinone compound (CoQ10 is a longer chained compound), it offers a superior level of bioavailability and maintains its functions much more efficiently.

By the choline-enhancing pathway, Idebenone is able to improve the activity of the neurotransmitter acetylcholine in the brain. This leads to better memory and learning capacity along with an overall faster speed of recall in some people.

Higher levels of Acetylcholine stimulation can result in more synaptic plasticity which means your brain is able to learn and adapt even later in life. Some users also report experience a better ability to make decisions and clearer thoughts and overall cognition. Attention spans may be lengthened along with enhanced focus and concentration.

As an anti-oxidant, Idebenone also carries neuroprotective benefits. Not only will the body and brain be cleansed of free radicals and other toxins, but it helps to guard against additional damage from occurring.

Side Effects & Dosages

Idebenone does not have any significant side effects, and with controlled use is considered safe. Generally recommended dosage ranges for those looking to achieve cognitive benefits from Idebenone is between 500 and 1,000 mg daily. It’s best for anyone considering using Idebenone to start with the lowest effective dose and adjust from there, preferably in the range of 200 or 300 mg.

Another great option for users is to combine Idebenone with a quality Choline supplement. Alpha GPC, CDP Choline (Citicoline), and Centrophenoxine are all superb examples of nootropic additives to stack with Idebenone.

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