Found in the moss plant Huperzia Serrata, Huperzine A is an organic alkaloid that acts as an acetylcholinesterase inhibitor, preventing the body from breaking down the compound acetylcholine. It is highly potent, generally regarded as safe, and can be found over the counter in many different nootropic supplements.



Huperzine A impacts the cholinergic system of the brain by inciting larger levels of the neurotransmitter acetylcholine, enhancing the speed and efficiency in which neurons within the brain pass information to one another. It also works as an NDMA receptor antagonist by fighting against its carcinogen properties to promote an increase in the release of NGF (Nerve Growth Factor), an essential protein used in the growth of nerve cells. This helps to maintain the health and efficiency of existing neurons within the brain, and can even assist in the creation of new ones.This process improves the user’s overall concentration, level of reasoning, and memory, and can even help in the treatment of Alzheimer’s disease.

Side effects

Generally regarded as safe when taken in its recommended dosages, Huperzine A nonetheless comes with the risk of minor side effects. Mild reactions include but are not limited to: headaches, nausea, high blood pressure, and excessive sweating. Those pregnant or breastfeeding are discouraged from using Huperzine A, as well as those with heart problems, seizure disorders, or urinary tract blockages. Always consult with a qualified physician in the case of questions that could affect any facet of use.

Dosages & Stacks

Huperzine A is a highly concentrated compound, which means that smaller dosages can provide adequate cognitive enhancing effects.

Recommended dosages for Huperzine A fall in-between 100 – 200 mcg daily, and 400 mcg in the case of its use for Alzheimer’s. Combining Huperzine A with other supplements can enhance the effects of the compound, and members of the racetam family, as well as cholinergic supplements such as Alpha GPC or Citicoline, make for solid choices that will improve results.

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