An antidepressant discovered 30 years ago in Central Europe, deprenyl is a prescription drug used for many different medical purposes, such as its use as a treatment for Parkinson’s disease during the 1990’s. It is sorted into a class of medications known as Phenethylamines: naturally occurring chemicals that help to improve physical performance, depression, and mood.



Deprenyl is commonly prescribed as an MAO-B inhibitor, controlling the job that MAO-B (an enzyme that breaks down dopamine in the brain) starts in an effort to increase and maintain higher dopamine levels. It is successful by exciting the dopamine neurons in the substantia nigra, a crucial structure in the midbrain. Deprenyl is also neuroprotective; enhancing the health of existing and already damaged neurons and other brain cells by protecting them from various toxins. Research on deprenyl is not comprehensive however, so it is not known whether these effects exist because of its properties as an antioxidant or by any other means. The enhancement of neural growth factors such as catalase and glutathione is another effect, and deprenyl curiously metabolizes into methamphetamine, although the process does not lead to any forms of addiction. The benefits of all of these processes can include the elevation of mood and the dampening of anxiety and depression. ​Dopamine is critical in maintaining both positive mood states and attention and movement control.

Side Effects & Dosages

If taken as prescribed, deprenyl is considered to be generally safe. However, common side effects can include an upset stomach, heartburn, nausea, and insomnia. It is important to note that deprenyl is considered a stimulant, and so it is metabolized into methamphetamine in the human body, despite its lack of addiction. 10 mg daily has been known to produce little to no side effects, but a professional medical opinion is important for information related to individual specific consumption.

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