Citicoline (CDP-Choline) is a high quality, water soluble choline source, known to be one of the more effective and safe choline supplements on the market today. It can improve many different mental processes such as an individual’s memory, learning potential, and mental focus, and can even help in the stability of one’s brainhealth. In addition, it can also serve as a highly effective portion of a nootropic stackwhen paired with many other supplements.



Choline, a nutrient much like the B vitamins necessary for the human brain to create acetylcholine, a compound in the central nervous system that acts as a neurotransmitter, is crucial for the most efficient brain activity possible. Originally developed in Japan, citicoline helps to regulate the amount of choline in the bloodstream to enhance the ability for neurons within the brain to communicate with one another. Upon taking citicoline, the compound flows into the bloodstream and quickly travels to the brain, where it works to increase the level of acetylcholine and is then broken down and used to enhance a number of different cognitive processes. Mental strength (which constitutes focus, concentration, and motivation) and memory recall speed are enhanced due to the improvement of blood circulation within the brain, increasing the organ’s oxygen intake and metabolism and making it operate more effectively. Clinically, citicoline has been used as a way to treat cerebral vascular disease, dementia, and head trauma. In addition, overall stress levels can decrease, and after the possible activation of a number of different antioxidants, the brain can work to rid itself of a plethora of poisons and toxins, greatly improving overall brain health.

Side effects

Side effects for citicoline are generally mild. These include headaches, diarrhea, insomnia, and nausea. It’s reported that these side effects only take place when consumption is higher than recommended.


Recommended dosages can vary depending on the specifics of the user, but general doses fall in-between the 500 to 2,000 mg range per day with citicoline tablets. It’s important to speak to a qualified physician for more information on what would be best for you.


It’s reported that the best results can be found when citicoline is used in conjunction with other nootropics. Other choline supplements such as Alpha GPC work well when paired with citicoline, as well as members of the racetam family, who could reduce the negative side effects to come from low choline levels in the body. Citicoline can either be purchased in a bulk powder form or in the way of brand name
products such as CerAxon, Cognizin, or the celebrated Iso Brain.

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