Ampalex is an ampakine compound nootropic that stimulates AMPA receptors, dramatically enhancing the speed and efficiency of synaptic communication between neurons. It also works with the neurotransmitter glutamate, impacting the speed of transmissions within excitatory synapses.

Currently in development by both Shire and RespireRx (formerly Cortex) Pharmaceuticals, data shows that it has the potential to treat Alzheimer’s disease, as well as ADHD. It has become the standard by which all other ampakine supplements are judged.



By stimulating receptor activity within the brain, the use of Ampalex leads to an enhanced state of mental focus and alertness, as well as a boost in physical energy. Other benefits include increased comprehension and reasoning skills.

Side effects

Common side effects are mild, and include but are not limited to: headaches, fatigue, nausea, or stomach issues.

One possible concern for Ampalex is in the form of an overstimulation of glutamate receptors, a phenomenon called excitotoxicity or over-excitement. This leads to an overabundance of brain activity and the eventual death of neurons.

This decline in cells can result in a cognitive imbalance, which can worsen the conditions of diseases like Alzheimer’s. However, it’s important to note that this effect is only theoretical, and has not been proven to occur during the use of ampakines.

Human trials are currently limited, and so it is currently recommended to use more established nootropics such as Noopept or Aniracetam. If ampalex is the nootropic of choice, then it’s also recommended to follow the instructions of a certified physician while taking the drug.

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