Adrafinil is a eugeroic, a class of drug that incites wakefulness and mental focus without the common side effects of psychostimulants, although it can seriously impact the health and effectiveness of a person’s liver. Previously prescribed as a treatment for narcolepsy, it is now gaining popularity as a nootropic capable of improving cognitive functions such as mental focus and stamina.

It was discovered in 1974 by a pair of French chemists who worked for Laboratoires Lafon, a pharmaceutical company that was in the process of discovering analgesics, or painkillers. To their surprise, adrafinil was found not to contain the properties necessary to suppress pain, but instead possessed the ability to promote hyperactivity. As a result, testing revealed that adrafinil was actually the prodrug for the compound modafinil, which meant that it was converted into modafinil whenever processed by the body to cause its mental enhancing properties.

Adrafinil is legal and does not need a prescription to be used in the United States. However, it has not been approved by the FDA to be used to treat any medical conditions.



Adrafinil travels to the liver after ingestion, where it metabolizes into modafinilic acid and the compound modafinil, the primary active component of the drug. This process results in the stimulation of the catecholamine hormones in what is called the adrenergic system, a portion of the central nervous system responsible for the release of epinephrine, which produces what is known as the adrenalin rush in the body.

The boosting of those hormones is what can increase the focus, energy levels, stamina, and learning capacity in the user’s mind. Adrafinil has also been used for euphoric purposes, as it can build a sense of well-being and reduce stress in its users.

In 2004, the World Anti-Doping Agency had modafinil placed on a list of banned substances for use in athletic purposes, due to its perceived performance enhancing benefits.

Side effects

Minor side effects include but are not limited to headaches, dizziness, stomach pains, and nausea. In addition, with significant use over long periods of time, Adrafinil has been shown to produce dangerous reactions pertaining to liver functionality. Since the drug is processed through the liver, an unhealthy build up of enzymes can occur if consumption of the drug is not monitored correctly. Combining adrafinil use with other substances that impact the function of the liver, such as alcohol, acetaminophen, and ibuprofen, can cause harm.

Adrafinil does not carry risks of dependency within its users or moves to affect their sleeping patterns. It is not known to affect the heart rate or elevate blood pressure, but some cardiovascular effects, such as heart palpitations or minor chest pains, are considered to be rare and typically mild.

Because of these side effects, it is generally recommended for a user to use modafinil instead of adrafinil if possible. However, if the user is healthy and follows any provided dosage instructions from a qualified physician, then any side effects are expected to be minor.


Generally, Adrafinil is recommended at daily dosages between 150 and 300 mg. Due to its potency as a nootropic however, it is advised to begin with small doses and increase them gradually as needed.

Because adrafinil powder is not water or fat soluble, it will not form a useable solution if mixed into other liquids. It is also bitter, and so is best consumed as a tablet or form of oral capsule. If long term use is desired, then a visit to a qualified physician or health care provider is recommended.


Adrafinil can be stacked with Noopept, Piracetam, Aniracetam, Pramiracetam, Oxiracetam, Phenylpiracetam, Phenibut, or Caffeine. But the best stacks are going to be dependent on user goals, as well as the various responses that the body will have to other compounds.

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