Acetylcholinesterase inhibitors are a class of compounds that promote learning by increasing an individual’s sensitivity to retaining knowledge. This is done by keeping the enzyme acetylcholinesterase in check, a strong neurotransmitter, which leads to improvements in logical and verbal reasoning and a healthy encouragement in the growth of neural structures within the brain.

These compounds regulate acetylcholinesterase by preventing too much of it from breaking down, which can threaten the balance of acetylcholine (a compound linked to the functions of memory storage, organization, and recall) within the brain and negatively affect attributes like memory retention and focus.

Types of Inhibitors

There are three main types of acetylcholinesterase inhibitors, which can be divided into either reversible, irreversible, or somewhere in between.


On one end, this class of compounds can can serve as conduits for memory enhancement, treatments for Alzheimer’s disease, and can even affect a person’s influence in lucid dreaming states.

Side Effects

On the other, they can be used as insecticides, can be weaponized to be used in the form of nerve agents, and have been classified as components for lethal venoms and poisons. This radical spectrum demonstrates the importance of the regulation of acetylcholine in the brain. Too much restriction of the enzyme can actually damage the physical and mental faculties of the mind, while smaller, careful dosages can help in enhancing the capability of the brain.

Best Supplements

There are two nutritional supplements that can be purchased as natural acetylcholinesterase inhibitors: Huperzine A & Galantamine. Huperzine A has been found to be more popular, and of the two, may be safer. Galantamine is generally considered to be stronger, since it’s typically used for the treatment of those diagnosed with Alzheimer’s disease.

Recommended Dosages

Only small dosages of Huperzine A are needed for impressive levels of memory enhancement. It’s recommended to start with a dose of two hundred micrograms per day for desired results. To put it to scale, one microgram is one thousand times smaller than one milligram. Huperzine A isa natural extract from the Huperzia Serrata tree, which is native to parts of India and throughout southeast Asia. It’s important to note that neither Huperzine A or Galantamine have been approved by the FDA to use to prevent or treat any existing conditions, including Alzheimer’s disease.


It’s also been found that taking Huperzine A in combination with a source of Choline can assist with desired results of memory enhancement. The following are a few common but effective examples of choline supplements to take: Citicoline, Centrophenoxine, and Alpha GPC (which can be found in Alpha Brain).

Racetams, another class of Cholinergic supplements, are another option. Racetams are a form of nootropic that increases the sensitivity of acetylcholine receptors. The following are a few examples that are both highly safe and offer impressive memory capacity benefits: Piracetam, Aniracetam, & Noopept.

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